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Anti-inflammatory effects of a major component of Acanthopanax senticosus Harms, isofraxidin.

작성자 비타메딕스(ip:)

작성일 2011-06-17

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Anti-inflammatory effects of a major component of Acanthopanax senticosus Harms, isofraxidin.

Accession number;04A0484822

Title;Anti-inflammatory effects of a major component of Acanthopanax senticosus Harms, isofraxidin.

Author;YAMAZAKI TAISUKE(Kohno Clin. Medical Res. Inst., JPN) SHIMOSAKA SHIGEHIRO(Romankogyo Saiboukogakuse) SAKURAI MASAYUKI(Romankogyo Saiboukogakuse) MATSUMURA TOSHIHARU(Romankogyo Saiboukogakuse) TSUKIYAMA TAKASHI(Kohno Clin. Medical Res. Inst., JPN) TOKIWA TAKAYOSHI(Kohno Clin. Medical Res. Inst., JPN)

Journal Title;Japanese Journal of Electrophoresis

Journal Code:G0565A

ISSN:0031-9082

VOL.48;NO.2;PAGE.55-58(2004)

Figure&Table&Reference;FIG.3, REF.14

Pub. Country;Japan

Language;Japanese

Abstract;The aim of this study is to investigate the effect of isofraxidin, which is a major component of Acanthopanax senticosus Harms, on cell growth and the expression of genes encoding IL-1.BETA., IL-6, MMP-1, and COX-2. For this purpose, a human synovial sarcoma cell line SW982 was used. Isofraxidin slightly inhibited the growth of SW982 cells at 450.MU.M, but significantly suppressed the gene expression of IL-1.BETA., IL-6, MMP-1, and COX-2 at 135.MU.M as well as at 450.MU.M. In addition, Isofraxidin supressed IL-6 production. These results suggest that isofraxidin exhibits anti-inflammatory effects. (author abst.)